Organ-on-a-chip

Liver-on-a-chip

We developed a liver-on-a-chip to simulate liver sinusoid, which incorporated 4 kinds of hepatic cells and artificial bile duct. On the basis of this liver-on-a-chip, we investigated the hepatotoxicity induced by drug-drug interaction and developed a disease model of alcoholic liver. Recently, we are invited to publish a review article about liver-on-a-chip on Micromachine (Micromachine, 2019,10, 676).
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Intestinal chip

We collaborated with IPE, CAS, and developed a peristaltic human gut-vessel microsystem for studying host–microbial interaction. On the basis of this device, we found that Lactobacillus casei was able to relieve the intestinal damage caused by E.coli.More is coming.
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Diabetes chip

We developed a two-organ-on-a-chip incorporating adipocytes and INS-1 cells, and simulated the pathogenesis of Type II diabetes, which was useful for assessment of the mechanism of treatment of type 2 diabetes by selected drugs.
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