菜单
Zhang's lab in Soochow University focuses on development of new methods and platforms for drug discovery from natural products, exploiting technologies including organ-on-a-chip, 3D bioprinting, organoid, multi-dimensional preparative chromatography, CLIP, etc. and provides service to pharmaceutical companies.
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Organ-on-a-chip
Faithful In vitro models for chronic complex diseases, such as NASH, Diabetes, IBD, Cancer, etc. are urgently needed for drug discovery. We use organ-on-a-chip technology to construct such models, and study compounds from natural product in the aspects of pharmacology, toxicity, and pharmacokinetics.
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3D-Bioprinting
We use 3D bioprinting technologies to develop in vitro models of NASH, IBD, diabetes, cancer, arteriosclerosis, etc, and use these models to study the pharmacology, toxicity, and pharmacokinetics of compounds from natural product.
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Organoid
We develop novel organoid-on-a-chip to test activity, toxicity and pharmacokinetics of drug candidates from natural product; meanwhile, we collaborate with hospitals to derive personalized organoid-on-a-chip, and perform personalized precision medicine studies.
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Multi-dimensional preparative chromatography
Chemical complexity of natural products raise challenges for separation and preparation of single compound from the original source. We develop several multi-dimensional preparative chromatographic methods, including reverse phase-reverse phase, HILIC-reverse phase, and ion exchange-reverse phase, etc., which enable fine separation and preparation of active species with ultra-high resolution and reproducibility.
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Cellular Label-free Integrative Pharmacology Profiling, CLIP
Natural products, like Traditional Chinese Medicine, cure disease depending on multiple components and multiple receptors in the cell. We use CLIP technology to identify the phenotypic activity and the targets of the active species simultaneously, which have significant implication of pharmacology of natural product.
News&Highlights
微信图片_20210102120651
2020-12-30
Invited to deliver a lecture entitled"New Technology Research of Natural Products" at Harbin Medical University.
微信图片_20201207211433
2020-12-06
Participated in the 4rd Forum on Innovation of Microfluidics, and delivered an invited lecture entitled"Pharmacodynamics and toxicology research based on Organ-on-a-chip and 3D bioprinting".
d7ce3e8e7f67a158e32937ccce0dadf
2020-11-28
Participated in the 8th Forum on Lab on a Chip Advances, and delivered an invited lecture entitled "Pharmacological and toxicological evaluation technology based on Organ-on-a-chip and 3D bioprinting".
拼图
2020-9-14
Welcome Quanfeng Deng, Lidan Liang and Linyu Wang joining in our group!
2020.4.3
2020-04-03
“Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review” was published on Micromachines, 2020, 11, 381.
2020.01.11gai
2020-01-11
Joining a seminar on “microfluidics and its applications in single cell analysis and tumor biology” held in Dalian University of Technology
2019-12-8新闻
2019-12-08
Participated in the 3rd Forum on Innovation of Microfluidics, and delivered an invited lecture entitled “Advanced In Vitro Models based on Organ-on-a-chip and 3D Bioprinting Technologies".
第七届微流控芯片高端论坛1123
2019-11-24
Participated in the 7th Forum on Lab on a Chip Advances, and delivered a keynote speech entitled "Advanced In Vitro Models based on Organ-on-a-chip and 3D Bioprinting Technologies".
2019-11-02
2019-11-02
Participated in the 13th world congress of regenerative medicine&stem Cell-2019, and delivered an invited talk entitled"Engineered liver-on-a-chip platform to mimic liver function".
图片1
2019-10-07
The paper entitled “Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review” was published on Micromachines, 2019, 10, 676
资讯照片1
2019-09-13
Joining in a seminar on "Application of organ-on-a-chip in toxicity evaluation of natural product" held in Shanghai University of Chinese Traditional Medicine.
图片6
2019-07-04
Welcome Youping Wang and Xiahe Han joining in our group!
文献1
2019-06-20
The paper entitled"A liver-chip-based alcoholic liver diaease model featuring multi-non-parenchymal cells" was on-line published on Biomedical Microdevices,2019,21:57
资讯3
2019-06-12
Prof. Ning Fang from Georgia State University visited the group and delivered a lecture entitled “Five dimensional single particle tracking reveals rotational motion in live cells".
新闻稿
   2023
              A special issue on "Organ Mimicking Technologies and Their Applications in Drug Discovery" has been launched in the Frontiers in Bioengineering and Biotechnology, with Prof. Xiuli Zhang as Guest Editor. (https://www.frontiersin.org/research-topics/36668).
2020-12-30
微信图片_20210102120651
Invited to deliver a lecture entitled"New Technology Research of Natural Products" at Harbin Medical University.
2020-12-06
微信图片_20201207211433
Participated in the 4rd Forum on Innovation of Microfluidics, and delivered an invited lecture entitled"Pharmacodynamics and toxicology research based on Organ-on-a-chip and 3D bioprinting".
2020-11-28
d7ce3e8e7f67a158e32937ccce0dadf
Participated in the 8th Forum on Lab on a Chip Advances, and delivered an invited lecture entitled "Pharmacological and toxicological evaluation technology based on Organ-on-a-chip and 3D bioprinting".
2020-09-14
拼图
Welcome Quanfeng Deng, Lidan Liang and Linyu Wang joining in our group!
2020-04-03
2020.4.3
“Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review” was published on Micromachines, 2020, 11, 381.
2020-01-11
2020.01.11gai
Joining a seminar on “microfluidics and its applications in single cell analysis and tumor biology” held in Dalian University of Technology.
2019-12-08
2019-12-8新闻
Participated in the 3rd Forum on Innovation of Microfluidics, and delivered an invited lecture entitled “Advanced In Vitro Models based on Organ-on-a-chip and 3D Bioprinting Technologies".
2019-11-24
第七届微流控芯片高端论坛1123
Participated in the 7th Forum on Lab on a Chip Advances, and delivered a keynote speech entitled "Advanced In Vitro Models based on Organ-on-a-chip and 3D Bioprinting Technologies".
2019-06-20
资讯2缩略图
The paper entitled"A liver-chip-based alcoholic liver diaease model featuring multi-non-parenchymal cells" was on-line published on Biomedical Microdevices,2019,21:57.
2019-06-12
资讯3
Prof. Ning Fang from Georgia State University visited the group and delivered a lecture entitled “Five dimensional single particle tracking reveals rotational motion in live cells".
2019-11-02
2019-11-02
Participated in the 13th world congress of regenerative medicine&stem Cell-2019, and delivered an invited talk entitled"Engineered liver-on-a-chip platform to mimic liver function".
2019-10-02
图片1
The paper entitled “Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review” was published on Micromachines, 2019, 10, 676.
2019-09-23
资讯照片1
Joining in a seminar on "Application of organ-on-a-chip in toxicity evaluation of natural product" held in Shanghai University of Chinese Traditional Medicine.
2019-07-04
资讯1
Welcome Youping Wang and Xiahe Han joining in our group!
Sponsors
苏大
宁波大学
深圳市科创委
苏大
宁波大学
深圳市科创委